E W S T U D Y F O R M A I N E C
O O N C A T S
Interaction between genetic and nutritional factors in
the development of
hypertrophic cardiomyopathy in Maine Coon cats
cardiomyopathy (HCM) is the most common heart disease in cats, occurring in
15-20% of the general feline population. HCM
involves a thickened heart muscle which can cause dysfunction of the heart with
secondary problems, such as congestive heart failure, blood clots, and sudden
death. While genetic mutations have
been identified in some cats (especially the Maine Coon cat which can have a
mutation in the myosin binding protein C gene) as a cause for the disease, the
severity of the disease varies widely and cannot be accounted for only by the
mutation. Therefore, environmental
modifiers, especially nutrition, likely play a role and the interactions between
genes and nutrients provide a promising target for modulation of disease.
The purpose of this study is to measure body size and nutritional factors
in Maine Coon cats with and without the myosin binding protein C mutation to
determine what relationship exists between nutrients, genetic mutations, and
heart muscle thickening. This will provide the basis for future research, a
better understanding of HCM, and the opportunity to advance the treatment of
this disease in cats.
Coon cats (male or female) that are at least two years of age.
Cats can be with or without known heart disease.
Owners must be willing to bring their cat to Tufts Cummings School of
Veterinary Medicine in North Grafton, MA for a single 1-2 hour visit.
with other major diseases (such as cancer, diabetes mellitus, or unregulated
hyperthyroidism) will be excluded. If
taking heart medications, cats must be on stable medications for at least 1
for one outpatient visit will be covered by the study.
This includes registration, examination, echocardiogram, x-ray, blood
pressure, and blood tests (including DNA testing for MYBPC3 mutation).
study will be starting in June. For
more information, please contact:
Freeman 508-839-5395 x84696 or firstname.lastname@example.org
For information on other clinical trials taking place at Tufts, please see our
Clinical Trials Website